Northampton Town F.C., Oxford United F.C. en Bristol Rovers F.C. zijn gepromoveerd naar de Engelse League One 2016/2017.
Accrington Stanley F.C., Plymouth Argyle F.C., Portsmouth F.C. en AFC Wimbledon zijn gekwalificeerd voor de Engelse League Two Promotie Play-Offs 2015/2016.
Dagenham & Redbridge F.C. en York City F.C. zijn gedegradeerd naar de Engelse National League 2016/2017.
Engelse League Two 2015/2016
| Pos | Club | P | W | D | L | F | A | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Northampton Town F.C. | 46 | 29 | 12 | 5 | 82 | 46 | 36 | 99 |
| 2 |  Oxford United F.C. | 46 | 24 | 14 | 8 | 84 | 41 | 43 | 86 |
| 3 |  Bristol Rovers F.C. | 46 | 26 | 7 | 13 | 77 | 46 | 31 | 85 |
| 4 |  Accrington Stanley F.C. | 46 | 24 | 13 | 9 | 74 | 48 | 26 | 85 |
| 5 |  Plymouth Argyle F.C. | 46 | 24 | 9 | 13 | 72 | 46 | 26 | 81 |
| 6 |  Portsmouth F.C. | 46 | 21 | 15 | 10 | 75 | 44 | 31 | 78 |
| 7 |  AFC Wimbledon | 46 | 21 | 12 | 13 | 64 | 50 | 14 | 75 |
| 8 |  Leyton Orient F.C. | 46 | 19 | 12 | 15 | 60 | 61 | -1 | 69 |
| 9 |  Cambridge United F.C. | 46 | 18 | 14 | 14 | 66 | 65 | 1 | 68 |
| 10 |  Carlisle United F.C. | 46 | 17 | 16 | 13 | 67 | 62 | 5 | 67 |
| 11 |  Luton Town F.C. | 46 | 19 | 9 | 18 | 63 | 61 | 2 | 66 |
| 12 |  Mansfield Town F.C. | 46 | 17 | 13 | 16 | 61 | 53 | 8 | 64 |
| 13 |  Wycombe Wanderers F.C. | 46 | 17 | 13 | 16 | 45 | 44 | 1 | 64 |
| 14 |  Exeter City F.C. | 46 | 17 | 13 | 16 | 63 | 65 | -2 | 64 |
| 15 |  Barnet F.C. | 46 | 17 | 11 | 18 | 67 | 68 | -1 | 62 |
| 16 |  Hartlepool United F.C. | 46 | 15 | 6 | 25 | 49 | 72 | -23 | 51 |
| 17 |  Notts County F.C. | 46 | 14 | 9 | 23 | 54 | 83 | -29 | 51 |
| 18 |  Stevenage F.C. | 46 | 11 | 15 | 20 | 52 | 67 | -15 | 48 |
| 19 |  Yeovil Town F.C. | 46 | 11 | 15 | 20 | 43 | 59 | -16 | 48 |
| 20 |  Crawley Town F.C. | 46 | 13 | 8 | 25 | 45 | 78 | -33 | 47 |
| 21 |  Morecambe F.C. | 46 | 12 | 10 | 24 | 69 | 91 | -22 | 46 |
| 22 |  Newport County A.F.C. | 46 | 10 | 13 | 23 | 43 | 64 | -21 | 43 |
| 23 |  Dagenham & Redbridge F.C. | 46 | 8 | 10 | 28 | 46 | 81 | -35 | 34 |
| 24 |  York City F.C. | 46 | 7 | 13 | 26 | 51 | 87 | -36 | 34 |