Speelronde 24
Toeschouwers: 67.435.
Scheidsrechter: Juan Martínez Munuera.
Scoreverloop:
1-0 Lionel Messi 43. (strafschop)
Real Valladolid: Enes Ünal (11), Anuar (34), Míchel (70)
Season: 2018-2019
Real Valladolid16-02-2019 Vitesse vs Willem II
Speelronde 22
Toeschouwers: 14.186.
Scheidsrechter: Allard Lindhout.
Scoreverloop:
1-0 Bryan Linssen 5. (assist Max Clark)
2-0 Martin Ødegaard 59. (assist Navarone Foor)
2-1 Alexander Isak 61. (assist Evangelos Pavlidis)
3-1 Max Clark 79.
3-2 Evangelos Pavlidis 83. (rebound)
Vitesse: Oussama Darfalou (11), Navarone Foor (28), Matús Bero (54), Willem II: Thomas Meiβner (48), Daniel Crowley (64), Kristófer Kristinsson (90)
Willem II16-02-2019 Atalanta B.C. vs A.C. Milan
Speelronde 24
Toeschouwers: 20.801.
Scheidsrechter: Fabrizio Pasqua.
Scoreverloop:
1-0 Remo Freuler 33. (assist Josip Ilicic)
1-1 Krzysztof Piatek 45. (assist Ricardo Rodríguez)
1-2 Hakan Çalhanoglu 55.
1-3 Krzysztof Piatek 61. (assist Hakan Çalhanoglu)
Atalanta B.C.: Marten de Roon (18)
A.C. Milan16-02-2019 KVRS Waasland-Beveren vs K.A.A. Gent
K.A.A. Gent16-02-2019 Angers SCO vs OGC Nice
OGC Nice16-02-2019 AS Monaco FC vs FC Nantes
FC Nantes16-02-2019 S.V. Zulte Waregem vs K. Sint-Truidense V.V.
K. Sint-Truidense V.V.16-02-2019 K.V. Oostende vs K.A.S. Eupen
K.A.S. Eupen16-02-2019 SC Heerenveen vs PSV
Speelronde 22
Toeschouwers: 23.522.
Scheidsrechter: Jochem Kamphuis.
Scoreverloop:
1-0 Mitchell van Bergen 3. (assist Ben Rienstra)
2-0 Michel Vlap 25. (assist Nemanja Mihajlovic)
2-1 Gastón Pereiro 59. (vrije trap)
2-2 Donyell Malen 90. (assist Steven Bergwijn)
SC Heerenveen: Kik Pierie (58), Michel Vlap (60)
SC Heerenveen 
vs 
PSV
vs PSV16-02-2019 Heracles Almelo vs Fortuna Sittard
Speelronde 22
Toeschouwers: 10.568.
Scheidsrechter: Jeroen Manschot.
Scoreverloop:
1-0 Adrián Dalmau 1. (assist Mohammed Osman)
2-0 Adrián Dalmau 51. (assist Brandley Kuwas)
3-0 Jesper Drost 55.
4-0 Adrián Dalmau 60. (assist Mohammed Osman)
5-0 Kristoffer Peterson 70. (assist Brandley Kuwas)
6-0 Adrián Dalmau 78. (assist Dabney dos Santos)
Heracles Almelo: Adrián Dalmau (41), Tim Breukers (54), Dario Van Den Buijs (67)
Fortuna Sittard