Speelronde 4
Toeschouwers: 50.902.
Scheidsrechter: Serdar Gözübüyük.
Scoreverloop:
1-0 Klaas Jan Huntelaar 6. (assist David Neres)
2-0 Hakim Ziyech 71. (assist Justin Kluivert)
3-0 Klaas Jan Huntelaar 88. (assist Frenkie de Jong)
PEC Zwolle: Erik Bakker (90)
vs 
PEC ZwolleSpeelronde 4
Toeschouwers: 11.331.
Scheidsrechter: Danny Makkelie.
Scoreverloop:
0-1 Steven Berghuis 22. (assist Karim El Ahmadi)
0-2 Steven Berghuis 29. (assist Michiel Kramer)
0-3 Jean-Paul Boëtius 33.
1-3 Reuven Niemeijer 73. (rebound)
2-3 Reuven Niemeijer 81. (strafschop)
2-4 Sam Larsson 90. (assist Jens Toornstra)
Heracles Almelo: Kristoffer Peterson (87), Brahim Darri (90), Lerin Duarte (90)
Speelronde 4
Toeschouwers: 11.123.
Scheidsrechter: Dennis Higler.
Scoreverloop:
0-1 Nasser el Khayati 32. (strafschop)
1-1 Fran Sol 77. (assist Ismail Azzaoui)
1-2 Nasser el Khayati 86. (assist Ricardo Kishna)
Speelronde 3
Toeschouwers: 32.469.
Scheidsrechter: Antonio Mateu Lahoz.
Scoreverloop:
1-0 Ganso 46. (assist Nolito)
2-0 Wissam Ben Yedder 76. (assist Pablo Sarabia)
3-0 Nolito 90. (assist Sébastien Corchia)
SD Eibar: José Angel (30)
Speelronde 3
Toeschouwers: 30.150.
Scheidsrechter: Daniel Siebert.
Scoreverloop:
1-0 Mark Uth 27. (assist Andrej Kramaric)
2-0 Mark Uth 51. (assist Steven Zuber)
TSG 1899 Hoffenheim: Benjamin Hübner (30), Steven Zuber (64), Pavel Kaderábek (65)
Speelronde 3
Toeschouwers: 39.457.
Scheidsrechter: Michael Fabbri.
Scoreverloop:
1-0 Përparim Hetemaj 17. (eigen doelpunt)
2-0 Gonzalo Higuaín 58. (assist Miarlem Pjanic)
3-0 Paulo Dybala 83. (assist Federico Bernardeschi)
A.C. Chievo Verona: Përparim Hetemaj (22)
Speelronde 3
Toeschouwers: 43.859.
Scheidsrechter: José González González.
Scoreverloop:
Valencia CF: Martín Montoya (35)
Feyenoord
ADO Den Haag
SD Eibar
FC Bayern München
Excelsior Maassluis
BVV Barendrecht
A.C. Chievo Verona
Atlético Madrid
Hannover 96